There were nine distinct paths running into Wyoming: four from the Forks of the Susquehanna and five from the Delaware River. From Sunbury (then known as Shamokin) the Wyoming path ran up the east branch of the Susquehanna. The pathway which ran from Shamokin to Wyoming followed the east side of the Susquehanna River through Catawissa, Mifflinville, Nescopeck, Wapwallopen, and Nanticoke. The Susquehanna River Basin is the second largest - next to the Ohio River Basin - east of the Mississippi River. The 444 miles of the Susquehanna drain 27,500 square miles covering large parts of New York, Pennsylvania and Maryland before emptying into the Chesapeake Bay. Two separate Susquehanna River Basin watersheds drain portions of south-central New York State: The Upper Susquehanna Watershed (discussed here) and the Chemung River Watershed (addressed separately). Jun 18, 2019 · Susquehanna River: From its origin at Otsego Lake in Cooperstown, it flows for over 440 miles and empties into the Chesapeake Bay in Maryland. In New York, it flows through Otsego, Chenango ...